By Stewart Simon
A Clinician's consultant to Pulmonary Arterial high blood pressure, moment version complements the general 'PAH information' of the broader medical group, and descriptions the necessity for screening, powerful analysis and useful remedy. subject matters comprise:
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Extra info for A Clinician's Guide to Pulmonary Arterial Hypertension: Pocketbook, 2nd edition
112 Several other studies are underway to assess the clinical efficacy of a number of other phosphodiesterase inhibitors and the results are also eagerly awaited to determine their definite role in treating PAH. Combination therapy There is significant interest in applying combination therapy (as opposed to monotherapy) with a prostacyclin analogue, endothelin receptor antagonist, or phosphodiesterase type 5 inhibitor to (once again) dramatically improve typically poor health outcomes associated with PAH.
Qxd 11/27/2007 7:48 PM Page 36 It should be noted that dose-related liver function abnormalities were noted in all of these studies: with the abnormalities reversible with dose titration (reduction) or cessation of treatment. 104 Sitaxsentan is also an oral ETA receptor antagonist. Sitaxsentan has demonstrated significant improvements in 6MWT and functional class in patients with idiopathic PAH, PAH associated with connective tissue disease, and a small cohort of patients with congenital heart disease (NYHA Class II and III).
115. Jamieson SW. Pulmonary thromboendarterectomy. Heart 1998; 79: 118–20. 116. Mayer E, Dahm M, Hake U et al. Mid-term results of pulmonary thromboendarterectomy for chronic thromboembolic pulmonary hypertension. Ann Thorac Surg 1996; 61: 1788–92. 117. Moser KM, Auger WR, Fedullo PF et al. Chronic thromboembolic pulmonary hypertension: clinical picture and surgical treatment. Eur Respir J 1992; 5: 334–42. 118. Reitz BA, Wallwork JL, Hunt SA et al. Heart–lung transplantation: successful therapy for patients with pulmonary vascular disease.
A Clinician's Guide to Pulmonary Arterial Hypertension: Pocketbook, 2nd edition by Stewart Simon
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