Antidotes: Principles and Clinical Applications - download pdf or read online

By Robert Flanagan, Alison Jones, Robert L Maynard

ISBN-10: 0748409653

ISBN-13: 9780748409655

Antidotesprovides up to date info at the improvement, their proposed mechanism of motion, toxicity, availability and functional features in their scientific use. The antidotes mentioned are essentially these both in present use, or into account or improvement. The ebook includes details at the antidotal remedy of poisoning with compounds encountered not just in Western Europe, North the United States and Australia, but in addition in constructing international locations. It covers resource, shelf lifestyles and cases the place antidote management complicates or compromises laboratory research.

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Therapeutic trends in the treatment of barbiturate poisoning: the Scandinavian method. Clin Pharmacol Ther 1961; 2: 220–9. Coby DG, Fiser RH, Decker WJ. Re-evaluation of the use of activated charcoal in the treatment of acute poisoning. Pediatr Clin N Am 1970; 17: 545–56. Corner GW. Mithridatium and theriac, the most famous remedies of old medicine. Johns Hopkins Med Bull 1915; 26: 222–6. Coturri E. De Theriaca ad Pisonem. Florence: Olschki, 1959. Cowan DL. Expunctum est mithridatium. Pharmaceut Hist 1985; 15(3): 2–3.

This latter purgative regime, with the addition of oral dosage with a mixture of arsenic trioxide, potassium carbonate, peppermint water, laudanum (tincture of opium) and lemon juice, was also advocated for snake bite, but only after cauterization of the bite site with a white-hot iron, concentrated sulphuric acid, boiling oil or some other caustic agent (Orfila, 1818)! 7) aimed not only to induce vomiting, but also to neutralize the poison, and is notable for its list of contraindicated (‘irritant’) substances.

Using frogs, dogs, cats, guinea pigs and rabbits, he demonstrated the potential benefits of charcoal in the management of strychnine poisoning. He also emphasized the importance of early utilization of charcoal and the use of the proper ratio of charcoal to poison. Other toxic substances, such as aconite, morphine, mercuric chloride and hemlock, were also studied. Subsequently, Benjamin Howard Rand (1827–1883) of Philadelphia reported a number of animal charcoal efficacy studies in a human subject, presumably himself.

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Antidotes: Principles and Clinical Applications by Robert Flanagan, Alison Jones, Robert L Maynard


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